Objectives of RABBIT:

1. Description of long-term efficacy of a treatment with biologics, of time spent under therapy, of reasons for a change in therapy as well as description of disease course under therapy and where applicable after end of therapy
   
2. Examination of long-term outcomes of biologic therapy compared to conventional DMARD therapy
   
3. Determination of direct and indirect costs of biologic therapy compared to conventional DMARD therapy

• prospective observational study with internal control group
• biologic group
• control group (those who change from one DMARD to another)
• observation period: at least 5 years
• measuring instruments: DAS28; ACR Response Criteria; continuity of therapy; record of adverse events; work disability and many more

Time required:

• In the first year: for all measurements (altogether) 1 hour per patient maximum
• From the second year on: 30-45 minutes per patient